MicroRNAs for Virus Pathogenicity and Host Responses, Identified in SARS-CoV-2 Genomes, May Play Roles in Viral-Host Co-Evolution in Putative Zoonotic Host Species.

摘要: Our recent study identified seven key microRNAs (miR-8066, 5197, 3611, 3934-3p, 1307-3p, 3691-3p, 1468-5p) similar between SARS-CoV-2 and the human genome, pointing at miR-related mechanisms in viral entry regulatory effects on host immunity. To identify putative roles of these miRs zoonosis, we assessed their conservation, compared with humans, some wild domestic animal carriers zoonotic viruses, including bat, pangolin, pig, cow, rat, chicken. Out under study, miR-3611 was most strongly conserved across all species; miR-5197 rat; miR-1307 human; miR-3691-3p miR-3934-3p pig followed by pangolin bat; miR-1468 while miR-8066 pig. In were conserved, miR-8066, miR-5197, miR-3334-3p least bat. Furthermore, that changes nucleotides can generate three new miRs, differing tissue distribution brain, lung, intestines, lymph nodes, muscle, different downstream KEGG pathways. This may be considerable importance as is localized spike protein transcript area genome. findings indicate for viral-host co-evolution hosts, particularly highlighting carriers, miRs' pathways linked to pathogenicity responses humans. silico paves way investigations into disease.