A T231E Mutant that Mimics Pathologic Phosphorylation of Tau in Alzheimer's disease Causes Activation of the Mitochondrial Unfolded Protein Response in C. elegans touch neurons.

作者: Keith Nehrke , Gail V W Johnson , Sanjib Guha , Anson Cheng , Sarah Fischer

DOI: 10.17912/MICROPUB.BIOLOGY.000306

关键词: DiseasePhosphorylationCell biologyMutantMitochondrial unfolded protein responseBiologyText mining

摘要:

参考文章(21)
Kaihong Mi, Gail Johnson, The role of tau phosphorylation in the pathogenesis of Alzheimer's disease. Current Alzheimer Research. ,vol. 3, pp. 449- 463 ,(2006) , 10.2174/156720506779025279
Christopher F. Bennett, Helen Vander Wende, Marissa Simko, Shannon Klum, Sarah Barfield, Haeri Choi, Victor V. Pineda, Matt Kaeberlein, Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans Nature Communications. ,vol. 5, pp. 3483- 3483 ,(2014) , 10.1038/NCOMMS4483
Jenni Durieux, Suzanne Wolff, Andrew Dillin, The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity Cell. ,vol. 144, pp. 79- 91 ,(2011) , 10.1016/J.CELL.2010.12.016
Rodrigo A. Quintanilla, Rommy von Bernhardi, Juan A. Godoy, Nibaldo C. Inestrosa, Gail V.W. Johnson, Phosphorylated tau potentiates Aβ-induced mitochondrial damage in mature neurons. Neurobiology of Disease. ,vol. 71, pp. 260- 269 ,(2014) , 10.1016/J.NBD.2014.08.016
Alexandre Paix, Andrew Folkmann, Dominique Rasoloson, Geraldine Seydoux, High Efficiency, Homology-Directed Genome Editing in Caenorhabditis elegans Using CRISPR-Cas9 Ribonucleoprotein Complexes Genetics. ,vol. 201, pp. 47- 54 ,(2015) , 10.1534/GENETICS.115.179382
Cole M. Haynes, Kseniya Petrova, Cristina Benedetti, Yun Yang, David Ron, ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans. Developmental Cell. ,vol. 13, pp. 467- 480 ,(2007) , 10.1016/J.DEVCEL.2007.07.016
Cristina Benedetti, Cole M. Haynes, Yun Yang, Heather P. Harding, David Ron, Ubiquitin-Like Protein 5 Positively Regulates Chaperone Gene Expression in the Mitochondrial Unfolded Protein Response Genetics. ,vol. 174, pp. 229- 239 ,(2006) , 10.1534/GENETICS.106.061580
JESÚS AVILA, JOSÉ J. LUCAS, MAR PÉREZ, FÉLIX HERNÁNDEZ, Role of tau protein in both physiological and pathological conditions. Physiological Reviews. ,vol. 84, pp. 361- 384 ,(2004) , 10.1152/PHYSREV.00024.2003
Dennis J. Selkoe, Alzheimer's Disease: Genes, Proteins, and Therapy Physiological Reviews. ,vol. 81, pp. 741- 766 ,(2001) , 10.1152/PHYSREV.2001.81.2.741