Brief communication: Potential drug targets in Mycobacterium tuberculosis through metabolic pathway analysis

作者: Sharmila Anishetty , Mrudula Pulimi , Gautam Pennathur

DOI: 10.1016/J.COMPBIOLCHEM.2005.07.001

关键词: Drug designDrug resistanceMetabolic pathwayBiochemistryKEGGMycobacterium Tuberculosis Structural Genomics ConsortiumComputational biologyMycobacterium tuberculosisProteomicsBiologyProteome

摘要: … a strategy of comparative metabolic pathway analysis. The enzymes in the pathways of M. … MbtG is therefore one of the important drug targets found by our approach and is also under …

参考文章(43)
Köster W, Hantke K, Braun, Bacterial iron transport: mechanisms, genetics, and regulation. Metal Ions in Biological Systems. ,vol. 35, pp. 67- 145 ,(1998)
H. R. Perkins, Microbial Cell Walls and Membranes Springer Netherlands. ,(1980) , 10.1007/978-94-011-6014-8
D. C. Crick, S. Mahapatra, P. J. Brennan, Biosynthesis of the arabinogalactan-peptidoglycan complex of Mycobacterium tuberculosis Glycobiology. ,vol. 11, pp. 25- 39 ,(2001) , 10.1093/GLYCOB/11.9.107R
Luis E.N. Quadri, Jason Sello, Thomas A. Keating, Paul H. Weinreb, Christopher T. Walsh, Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin. Chemistry & Biology. ,vol. 5, pp. 631- 645 ,(1998) , 10.1016/S1074-5521(98)90291-5
PE Kolattukudy, Norvin D Fernandes, AK Azad, Ann Marie Fitzmaurice, Tatiana D Sirakova, None, Biochemistry and molecular genetics of cell-wall lipid biosynthesis in mycobacteria Molecular Microbiology. ,vol. 24, pp. 263- 270 ,(1997) , 10.1046/J.1365-2958.1997.3361705.X
Matti Saraste, Peter R. Sibbald, Alfred Wittinghofer, The P-loop--a common motif in ATP- and GTP-binding proteins. Trends in Biochemical Sciences. ,vol. 15, pp. 430- 434 ,(1990) , 10.1016/0968-0004(90)90281-F
R. A. Laskowski, M. W. MacArthur, D. S. Moss, J. M. Thornton, PROCHECK: a program to check the stereochemical quality of protein structures Journal of Applied Crystallography. ,vol. 26, pp. 283- 291 ,(1993) , 10.1107/S0021889892009944