EXTRACELLULAR MATRIX | Matricellular Proteins

摘要: The term ‘matricellular’ was coined to identify a group of proteins that are secreted and function in the extracellular matrix, but do not play structural role as an integral component physical entity such fiber or basement membrane. Instead, matricellular primarily serve modulate cell function. These functions achieved part by interaction with variety cell-surface receptors, resulting engagement signal transduction pathways. Matricellular also capable interacting matrix proteins, collagens fibronectin, number bioactive is, cytokines, growth factors, proteases. As consequence, these molecules can either be sequestered presented their appropriate case proteases, inhibited direct binding cleared from pericellular environment formation protein–enzyme complexes recognized scavenger receptor. It should noted, however, distinction between is sharp, since collagens, laminins, fibronectin influence they bind proteins. The classification based on similarity mode action rather than homology amino acid sequence three-dimensional structure. Thus, thrombospondins, SPARC family members, tenascins, CCN osteopontin, core considered this chapter, structurally unrelated. partial dependence which interact gives rise characterization contextual. relevance biochemistry physiology lung will therefore depend large extent co-expression proteins. frequently expressed pulmonary fibrosis neoplasms lung, early evidence supports ability progress disorders.