Structural determinants of T-cell receptor bias in immunity

摘要: Antigen-specific T-cell responses induced by infection, transplantation, autoimmunity or hypersensitivity are characterized cells expressing biased profiles of receptors (TCRs) that selected from a diverse, naive repertoire. Here, we review the evidence for these TCR biases, focusing on crystallographic analysis structural constraints determine binding to its ligand and persistence certain TCRs in an immune We discuss ways which diversity repertoire can contribute protective immunity implications this vaccine design immunotherapy.