Reversibly Switching Bilayer Permeability and Release Modules of Photochromic Polymersomes Stabilized by Cooperative Noncovalent Interactions.
作者： Xiaorui Wang , Jinming Hu , Guhuan Liu , Jie Tian , Huijuan Wang
DOI: 10.1021/JACS.5B10127
关键词: Spiropyran 、 Merocyanine 、 Polymersome 、 Monomer 、 Lipid bilayer 、 Photochromism 、 Bilayer 、 Non-covalent interactions 、 Photochemistry 、 Chemistry 、 Polymer chemistry
摘要: We report on the fabrication of photochromic polymersomes exhibiting photoswitchable and reversible bilayer permeability from newly designed poly(ethylene oxide)-b-PSPA (PEO-b-PSPA) diblock copolymers, where SPA is spiropyran (SP)-based monomer containing a unique carbamate linkage. Upon self-assembling into polymersomes, SP moieties within vesicle bilayers undergo phototriggered isomerization between hydrophobic (SP, λ2 > 450 nm irradiation) zwitterionic merocyanine (MC, λ1 < 420 states. For both MC their microstructures are stabilized by multiple cooperative noncovalent interactions including hydrophobic, hydrogen bonding, π–π stacking, paired electrostatic (zwitterionic) interactions, with latter two types being exclusive for polymersomes. Control experiments using analogous block copolymers carbonate linkage (SPO) conventional methacrylate (SPMA) single ester f...
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