Oral insulin delivery systems based on complexation polymer hydrogels

摘要: The potential of complexation hydrogels composed poly(methacrylic acid) grafted with poly(ethylene glycol) (P(MAA-g-EG)) for oral dosage forms insulin is reviewed. exhibit unique pH-responsive characteristics in which interpolymer complexes are formed and dissociated, respectively, acidic neutral/basic environments. capable highly incorporating rapidly releasing vitro possess mucoadhesive properties calcium binding capacities affect the proteolytic activity calcium- dependent enzymes. insulin-loaded P(MAA-g-EG) (ILP) successfully enhanced absorption without detectable mucosal damage following administration to normal, type 1 2 diabetic rats via route. Furthermore, ILP significantly suppressed postprandial rise blood glucose showed continuous hypoglycemic effects multiple presence foods. These results indicate that levels diabetics can be effectively controlled by administration. Based on these data it anticipated will used clinical development delivery system, as application may avoid suffering from injection pain poor compliance patients.