作者: Abbas Ali , Yan-Hong Wang , Ikhlas A. Khan
DOI: 10.1093/JME/TJV072
关键词: Toxicology 、 Traditional medicine 、 Essential oil 、 Larvicide 、 DEET 、 Biology 、 Curcuma 、 Aedes 、 Bioassay 、 Aedes aegypti 、 Rhizome
摘要: Essential oils and extract of Curcuma longa, ar-turmerone, curcuminoids were evaluated for their larvicidal deterrent activity against mosquitoes. Ar-turmerone constituted 36.9, 24.9 50.6% rhizome oil, leaf extract, respectively. was the major compound oil (36.9%) (24.9%). The ethanolic had 15.4% ar-turmerone with 6.6% bisdesmethoxycurcumin, 6.1% desmethoxycurcumin, 22.6% curcumin. In in vitro studies, essential (biting deterrence index [BDI] = 0.98), (BDI = 0.98), (BDI = 0.96) at 10 µg/cm(2) showed biting similar to DEET 25 nmol/cm(2) Aedes aegypti L. Among pure compounds, (BDI = 1.15) higher than whereas other compounds lower DEET. Anopheles quadrimaculatus Say, only dose-response bioassay, significantly all dosages. Ar-turmerone, 15 nmol/cm(2), 5 nmol/cm(2) 20 15 nmol/cm(2). Leaf LC(50) values 1.8 8.9 ppm larvae An. Ae. aegypti, respectively, highest toxicity followed by extract. 2.8 2.5 ppm most toxic curcumin, desmethoxycurcumin.