Hepatitis E virus in Common voles (Microtus arvalis) from an urban environment, Hungary: Discovery of a Cricetidae-specific genotype of Orthohepevirus C.

摘要: Hepatitis E virus is a major causative agent of acute hepatitis worldwide. Despite its zoonotic potential, there limited information about the natural chain hepevirus infection in wildlife, and potential reservoir species. In this study, we performed HEV survey by heminested RT-PCR on rodent samples from an urban environment (in city Pecs, Hungary) investigated prevalence among these native species (Apodemus agrarius, Apodemus flavicollis, sylvaticus, Microtus arvalis Myodes glareolus). was detected exclusively Common voles (M. arvalis), 10.2% screened voles, 3.2% all Based phylogenetic analysis, our strain showed closest homology with European Orthohepevirus C strains previously faecal birds prey Red fox, supporting possibility dietary origin strains. addition, close relation South American Necromys lasiurus (Cricetidae), but separated clearly other Muridae-associated strains, suggesting presence Cricetidae-specific genotype Europe South-America. results, hypothesize role M. arvalis rodents for genotype.