Neuropeptide Y in Cortex and Striatum.

摘要: NPY-neurons in the striatum and cortex have many morphological chemical features common. They are intrinsic, medium sized, aspiny exhibit ultrastructural characteristics typical of neurons undergoing active synthesis release peptides. Most two regions coexist with somatostatin, high levels NADPH-diaphorase resistant to degeneration associated Huntington's disease. Ultrastructural analysis suggests that ensheathment by glia sparsity asymmetric (putatively excitatory) inputs may render NPY excitotoxicity. Although receive few inputs, they make numerous contacts dendrites within a small region neuropil. Among their targets GABAergic neurons. These NPY-receptive GABA differ from other vicinity along somata proximal dendrites. This exert more influence on specific class Many NPY-terminals found at sites would be strategic for simultaneous modulation transmitters postsynaptic responses. The differences among versus cerebral mainly chemical. notably, not striatum. In addition, some NPY-axons ventral portions catecholaminergic, thus originate brainstem areas recognized contain epinephrine or norepinephrine. NPY- catecholaminergic fibers converge onto same Thus, interact through intercellular biochemical pathways postsynaptically. Finally, where directly contact each stimulates turnover dopamine.