Le rôle des phénomènes aléatoires dans le cancer
作者： Jean-Pascal Capp
DOI: 10.1051/MEDSCI/20143006023
关键词: Cancer genome sequencing 、 Computational biology 、 Genetic heterogeneity 、 Mutation 、 Disease 、 Cancer 、 Regulation of gene expression 、 Cancer cell 、 Epigenetics 、 Biology
摘要: In the reductionist perspective, genetic modifications are considered to initiate cancer. Their appearance is a stochastic phenomenon, but there some biases linked DNA sequence or exposure mutagenic agents for instance. Cancer genome sequencing has shown high inter- and intra-tumoral heterogeneity, sometimes questioning origin of Other processes also studied in cancer, especially epigenetic modifications. They have major role diversifying phenotypes among cancer cells progression steps, might provide an alternative theories initiation. Nevertheless, framework remains dominant here. Finally, cell-to-cell variations gene expression constitute third class phenomena that can be as causal factors Highlighting variability due disruption cellular interactions communications allows avoiding reductionism by considering interplay between tissue levels at every step disease. No organization level privileged this theory.
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