At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells

作者: Marilyn Kozak

DOI: 10.1016/0022-2836(87)90418-9

关键词: GeneticsShine-Dalgarno sequenceEukaryotic translationOpen reading frameLeaky scanningCodon usage biasStart codonKozak consensus sequenceBiologyConsensus sequence

摘要: … translation upon substitut’ing T for C in positions - 1 and -2, but no effect upon mutating positions … 1 hat C’ in positions -4 and -5 might yet facbilitate translation when part of a larger motif. …

参考文章(12)
H. van Ormondt, F. Galibert, Nucleotide Sequences of Adenovirus DNAs Current Topics in Microbiology and Immunology. ,vol. 110, pp. 73- 142 ,(1984) , 10.1007/978-3-642-46494-2_4
D Landsman, N Soares, F J Gonzalez, M Bustin, Chromosomal protein HMG-17. Complete human cDNA sequence and evidence for a multigene family. Journal of Biological Chemistry. ,vol. 261, pp. 7479- 7484 ,(1986) , 10.1016/S0021-9258(17)38417-X
Kathleen L. Barkner, Phillip A. Sharp, Expression of dihydrololate reductase, and of the adjacent Elb region, in an Ad5-dihydrofolate reductase recombinant virus Nucleic Acids Research. ,vol. 12, pp. 1925- 1941 ,(1984) , 10.1093/NAR/12.4.1925
A SHATKIN, Capping of eucaryotic mRNAs Cell. ,vol. 9, pp. 645- 653 ,(1976) , 10.1016/0092-8674(76)90128-8
Charles B. Lawrence, Kathy J. Jackson, Translation of adenovirus serotype 2 late messenger RNAs Journal of Molecular Biology. ,vol. 162, pp. 317- 334 ,(1982) , 10.1016/0022-2836(82)90529-0