Platelets in Atherosclerosis and Thrombosis

摘要: Rupture of an atherosclerotic plaque exposes a thrombogenic matrix, which instantly triggers platelet tethering and activation. We here delineate the sequence events during arterial thrombus formation dissect specific role various receptors in this process. also discuss interplay platelets with circulating immune cells, support thrombosis by fibrin process that involves extracellular nucleosomes. In second part chapter we describe lesion formation. Platelets adhere to dysfunctional endothelium early atherogenesis. They contain large machinery proinflammatory molecules, can be released upon their This prepares ground for subsequent leukocyte recruitment infiltration, boosts inflammatory wall. Together, play critical both acute chronic processes vascular wall, makes them attractive target pharmacological strategies treat and, potentially, atheroprogression.