First HAART in HIV-infected patients with high viral load: value of HIV RNA levels at 12 weeks to predict virologic outcome.
作者： David Townsend , Jesús Troya , Ivana Maida , Leticia Pérez-Saleme , Giovanni Satta
关键词: Virology 、 Viral load 、 In patient 、 VIROLOGIC FAILURE 、 Human immunodeficiency virus (HIV) 、 Hiv infected patients 、 Proportional hazards model 、 Internal medicine 、 Medicine 、 Viral rebound 、 Odds ratio
摘要: The aim of this study is to identify the role incomplete suppression during first months highly active antiretroviral treatment (HAART) predict virologic failure in patients with high levels HIV replication. In a retrospective, longitudinal, and multicenter study, response HAART was assessed treatment-naive adults RNA >100 000 copies/mL, factors predicting were analyzed through regression analyses. A total 118 included. Virologic occurred more often >500 copies/mL at week 12 (Cox regression: Exp (B) 3.22; P = .02). predicted (odds ratio [OR] 9.33; .002] but not viral rebound. Major resistant mutations present 11 14 patients. predicts replication baseline. Most carried resistance time fai...
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