Pharmacokinetic evaluation of D-ribose after oral and intravenous administration to healthy rabbits.

摘要: Introduction This study explored D-ribose pharmacokinetics after intravenous (IV) and oral administration to healthy rabbits. Materials methods was administered once as 420 mg/kg (N=4) or 840 (N=6) dose intravenously, an of (N=3) (N=3). Serum obtained at various time points, up 210 minutes administration. Urine also collected IV Pharmacokinetic parameters were determined from drug concentration-time data using Kinetica software. Results The findings showed that follows a dose-dependent kinetic profile. With doubling the dose, AUCtotal significantly increased by threefold, while clearance decreased 44%. half-life 1.7-fold longer higher dose. Similar nonsignificant trends observed rapidly absorbed (Tmax=36-44 minutes) disappeared plasma (within <140 minutes). Additionally, partially (18-37.5%) recovered urine. Conclusion Collectively, profile, where change according dosing levels. seems follow first-order kinetics low Thereafter, elimination systems are saturated, continues in fast manner. recovery partial, which could be attributed several metabolic pathways pentose can undergo.