Multicentre clinical trials of benzimidazolecarbamates in human echinococcosis.

摘要: Abstract Studies coordinated by the World Health Organization were conducted in seven clinical centres on chemotherapy of human echinococcosis with mebendazole, albendazole, and flubendazole. The first phase these ended following conclusions. Treatment 85 patients mebendazole for cystic (Echinococcus granulosus) was successful 8 partially 4 others. Flubendazole effective only one case lung echinococcosis. Albendazole 5 30 treated Further studies new drugs or formulations existing benzimidazoles better forms their application are needed. In mean time, should be restricted to inoperable cases. In 54 E. multilocularis echinococcosis, it confirmed that therapy may arrest development lesions. This treatment is therefore indicated most cases alveolar without surgery. However, further needed clarify optimal regimen explore effectiveness albendazole therapy.