An inhibitor from placenta specifically binds urokinase and inhibits plasminogen activator released from ovarian carcinoma in tissue culture.
作者： Lars Holmberg , Ingegerd Lecander , Bengt Persson , Birger Åstedt
DOI: 10.1016/0304-4165(78)90216-7
关键词: Placenta 、 Serine 、 Tissue culture 、 Urokinase receptor 、 Cancer research 、 Plasminogen activator 、 Immunology 、 Urokinase 、 Chemistry 、 Placental tissue 、 Ovarian carcinoma
摘要: Abstract An inhibitor present in placenta and released placental tissue culture forms specific complexes with each of two molecular urokinase. Audoradiography demonstrated that the shifted electrophoretic position 125 I-labelled It did not change migration diisopropyl-fluorophosphate-inactivated urokinase, thereby indicating complex formation dependent on active serine site The had a strong neutralizing effect plasminogen activators from human ovarian carcinoma culture. might prove useful inhibiting fibrinolytic process necessary for proliferation tumour vessels.
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