Link between CIITA rs3087456 polymorphism and the risk of laryngeal squamous cell carcinoma in a Chinese population.
作者： Yi Xue , Di Tang , Sheng-Jie Li , Jian Zhou , Chi-Yao Hsueh
DOI: 10.1016/J.PRP.2019.152793
关键词: CIITA Gene 、 Major histocompatibility complex 、 Genotype 、 Gene expression 、 CIITA 、 SNP 、 Biology 、 Cancer research 、 RFX5 、 Immunohistochemistry
摘要: Abstract The class II trans-activator (CIITA) is the master regulator of major histocompatibility complex (MHC) gene expression. CIITA mutations have been previously associated with several kinds tumors, while role polymorphisms (rs3087456) in laryngeal squamous cell carcinoma (LSCC) little known. We evaluate link between and existence LSCC patients. This study was conducted 200 Chinese Han patients healthy control subjects. association genetic polymorphism rs3087456 risk assessed through pyrosequencing. expression tumor tissue adjacent normal detected by immunohistochemistry (IHC) staining. relationship genotype controls clinical pathology features were analyzed, in-silico analysis also used for gene. results showed that closely related to genes such as RFX5 RFXAP. IHC highly expressed tissues, compared corresponding tissues. AG, AG + AA, A genotypes notably increased controls. Our suggests a higher developing cohort.
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