Comparative genomics of marine cyanomyoviruses reveals the widespread occurrence of Synechococcus host genes localized to a hyperplastic region: implications for mechanisms of cyanophage evolution

摘要: P>The vast majority of cyanophages isolated to date are cyanomyoviruses, a group related bacteriophage T4. Comparative genome analysis five including newly sequenced cyanophage S-RSM4, revealed 'core genome' 64 genes, the which also found in other T4-like phages. Subsequent comparative genomic hybridization using pilot microarray showed that number 'host' genes widespread cyanomyovirus isolates. Furthermore, hyperplastic region was identified between g15-g18, within highly conserved structural gene module, contained variable inserted lacked conservation order. Several these were host-like and included ptoX, gnd, zwf petE encoding plastoquinol terminal oxidase, 6-phosphogluconate dehydrogenase, glucose 6-phosphate dehydrogenase plastocyanin respectively. Phylogenetic analyses suggest acquired independently each other, even though they have become localized same region. This contains no detectable sequence features might be mechanistically involved with acquisition but does appear site specifically associated process may represent novel facet evolution marine cyanomyoviruses.