Tri-, tetra- and heptacyclic perylene analogues as new potential antineoplastic agents based on DNA telomerase inhibition

作者: Claudia Sissi , Lorena Lucatello , A. Paul Krapcho , David J. Maloney , Matthew B. Boxer

DOI: 10.1016/J.BMC.2006.09.029

关键词: DNAG-quadruplexSide chainCell killingSelectivityStereochemistryChemistryTelomeraseCircular dichroismPerylene

摘要: … paper we examined a number of perylene derivatives exhibiting different side chains to … modulated by reduction of the carbonyl groups. This was achieved either by reduction of the …

参考文章(23)
Philip J. Perry, Sharon M. Gowan, Anthony P. Reszka, Paolo Polucci, Terence C. Jenkins, Lloyd R. Kelland, Stephen Neidle, 1,4- and 2,6-Disubstituted Amidoanthracene-9,10-dione Derivatives as Inhibitors of Human Telomerase Journal of Medicinal Chemistry. ,vol. 41, pp. 3253- 3260 ,(1998) , 10.1021/JM9801105
Luigi Rossetti, Marco Franceschin, Stefano Schirripa, Armandodoriano Bianco, Giancarlo Ortaggi, Maria Savino, Selective interactions of perylene derivatives having different side chains with inter- and intramolecular G-quadruplex DNA structures. A correlation with telomerase inhibition. Bioorganic & Medicinal Chemistry Letters. ,vol. 15, pp. 413- 420 ,(2005) , 10.1016/J.BMCL.2004.10.061
N. Kim, M. Piatyszek, K. Prowse, C. Harley, M. West, P. Ho, G. Coviello, W. Wright, S. Weinrich, J. Shay, Specific association of human telomerase activity with immortal cells and cancer Science. ,vol. 266, pp. 2011- 2015 ,(1994) , 10.1126/SCIENCE.7605428
Haiyong Han, Carter L. Cliff, Laurence H. Hurley, Accelerated assembly of G-quadruplex structures by a small molecule. Biochemistry. ,vol. 38, pp. 6981- 6986 ,(1999) , 10.1021/BI9905922
Oleg Yu. Fedoroff, Miguel Salazar, Haiyong Han, Violetta V. Chemeris, Sean M. Kerwin, Laurence H. Hurley, NMR-Based Model of a Telomerase-Inhibiting Compound Bound to G-Quadruplex DNA† Biochemistry. ,vol. 37, pp. 12367- 12374 ,(1998) , 10.1021/BI981330N
Dong-Fang Shi, Richard T. Wheelhouse, Daekyu Sun, Laurence H. Hurley, Quadruplex-Interactive Agents as Telomerase Inhibitors: Synthesis of Porphyrins and Structure−Activity Relationship for the Inhibition of Telomerase Journal of Medicinal Chemistry. ,vol. 44, pp. 4509- 4523 ,(2001) , 10.1021/JM010246U
A. Ambrus, D. Chen, J. Dai, T. Bialis, R. A. Jones, D. Yang, Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution Nucleic Acids Research. ,vol. 34, pp. 2723- 2735 ,(2006) , 10.1093/NAR/GKL348