Low signal intensity lesions on brain susceptibility-weighted MRI in a patient with intravascular large B-cell lymphoma.
作者： Yo Tsuda , Takuya Oguri , Keita Sakurai , Tomohiro Kajiguchi , Hideki Kato
DOI: 10.5692/CLINICALNEUROL.CN-001027
关键词: Skin biopsy 、 Vincristine 、 Lymphoma 、 Intravascular large B-cell lymphoma 、 Bone marrow 、 Medicine 、 Pathology 、 Cyclophosphamide 、 Magnetic resonance imaging 、 Prednisone
摘要: A 71-year-old man was admitted to our hospital because of abnormal behavior and generalized convulsion. Brain MRI revealed no abnormalities upon admission. Levels serum lactate dehydrogenase soluble interleukin-2 receptors were significantly elevated, whereas the initial bone marrow puncture random skin biopsy findings non-malignant. On tenth day admission, brain dot strip-shaped low signal intensity lesions on susceptibility-weighted images (SWI) disseminated mainly within cerebral cortex. Administration high dose methyl-prednisolone improved neither his condition nor these findings. Ground-glass opacities bilateral lungs later emerged chest CT. The results a transbronchial lung second consistent with diagnosis intravascular large B-cell lymphoma (IVLBCL). Despite lack histopathological confirmation, intensities SWI in this case also considered IVLBCL lesions, reflective micro-hemorrhagic changes.
sci-hub.se 参考文章(9)
Daniel Thomas Ginat, Alixandra Purakal, Peter Pytel, Susceptibility-weighted imaging and diffusion-weighted imaging findings in central nervous system monomorphic B cell post-transplant lymphoproliferative disorder before and after treatment and comparison with primary B cell central nervous system lymphoma. Journal of Neuro-oncology. ,vol. 125, pp. 297- 305 ,(2015) , 10.1007/S11060-015-1903-1
Maria Grazia Passarin, Patrick Y. Wen, Emanuela Vattemi, Ebba Buffone, Claudio Ghimenton, Lamberto Bontempini, Sarah Ottaviani, Anna Maria Musso, Rebecca Pedersini, Intravascular lymphomatosis and intracerebral haemorrhage. Neurological Sciences. ,vol. 31, pp. 793- 797 ,(2010) , 10.1007/S10072-010-0284-7
Keiko Imamura, Etsuko Awaki, Yasuaki Aoyama, Shinji Kondo, Yasushi Horie, Eisaku Ohama, Kenji Nakashima, Intravascular large B-cell lymphoma following a relapsing stroke with temporary fever: a brain biopsy case. Internal Medicine. ,vol. 45, pp. 693- 695 ,(2006) , 10.2169/INTERNALMEDICINE.45.1621
Takuhei Murase, Motoko Yamaguchi, Ritsuro Suzuki, Masataka Okamoto, Yumiko Sato, Jun-ichi Tamaru, Masaru Kojima, Ikuo Miura, Naoyoshi Mori, Tadashi Yoshino, Shigeo Nakamura, Intravascular large B-cell lymphoma (IVLBCL): a clinicopathologic study of 96 cases with special reference to the immunophenotypic heterogeneity of CD5. Blood. ,vol. 109, pp. 478- 485 ,(2007) , 10.1182/BLOOD-2006-01-021253
Vivek Sehgal, Zachary Delproposto, E. Mark Haacke, Karen A. Tong, Nathaniel Wycliffe, Daniel K. Kido, Yingbiao Xu, Jaladhar Neelavalli, Djamel Haddar, Jürgen R. Reichenbach, Clinical applications of neuroimaging with susceptibility‐weighted imaging Journal of Magnetic Resonance Imaging. ,vol. 22, pp. 439- 450 ,(2005) , 10.1002/JMRI.20404
Yaling Ding, Zhen Xing, Biying Liu, Xinjian Lin, Dairong Cao, Differentiation of primary central nervous system lymphoma from high-grade glioma and brain metastases using susceptibility-weighted imaging Brain and behavior. ,vol. 4, pp. 841- 849 ,(2014) , 10.1002/BRB3.288
A. Yamamoto, Y. Kikuchi, K. Homma, T. O'uchi, S. Furui, Characteristics of Intravascular Large B-Cell Lymphoma on Cerebral MR Imaging American Journal of Neuroradiology. ,vol. 33, pp. 292- 296 ,(2012) , 10.3174/AJNR.A2770
Robert L Williams, Carolyn Cidis Meltzer, James G Smirniotopoulos, Melanie B Fukui, Mark Inman, None, Cerebral MR imaging in intravascular lymphomatosis. American Journal of Neuroradiology. ,vol. 19, pp. 427- 431 ,(1998)
Maurilio Ponzoni, Takuhei Murase, Andrés JM Ferreri, Shigeo Nakamura, Intravascular large B-cell lymphoma CRC Press. pp. 147- 154 ,(2008) , 10.3109/9780203091753-13