Heavy metal salts of succinic acid hemiesters with hyaluronic acid, or hyaluronic acid esters, a process for their preparation, and relative pharmaceutical compositions

作者: Paul A. Konowicz , Valentina Gombac , Antonella Flaibani , Riaz Khan

DOI:

关键词: Ester derivativesActive ingredientSuccinic acidMetal saltsHyaluronic acidChemistryDisinfectantOrganic chemistry

摘要: Hyaluronic acid or hyaluronic ester derivatives, wherein one more hydroxy functions of its 1,4-.beta.-D-glucuronic and 1,3-.beta.-N-acetyl-D-glucosamine alternating repeating units are esterified with a carboxyl group succinic to form the hemiester esters. These derivatives used prepare corresponding heavy metal salts hemiesters partial total as active ingredients in preparation pharmaceutical compositions be antibacterial disinfectant agents for treatment wounds, burns ophthalmia anti-inflammatory particular osteoarticular disorders.

参考文章(6)
S. T. Reed, D. C. Martens, Copper and zinc. Methods of Soil Analysis Part 3—Chemical Methods. pp. 703- 722 ,(2018) , 10.2136/SSSABOOKSER5.3.C26
Francesco Della Valle, Aurelio Romeo, Esters of hyaluronic acid ,(1986)
Hiroshi Hamana, Masahiro Kajiki, Toshiro Yano, Shuichi Sugawara, Satoshi Okuno, Keiji Yamamoto, Nobukazu Kashima, Hideo Nogusa, Kazuhiro Inoue, Polysaccharide derivatives and drug carriers ,(1994)