Overexpression of Cardiomyocyte α1A-Adrenergic Receptors Attenuates Postinfarct Remodeling by Inducing Angiogenesis Through Heterocellular Signaling

摘要: Objective—Stimulation of cardiac α1A-adrenergic receptors (α1A-AR) has been proposed for treatment heart failure, since it increases myocardial contractility. We investigated a different mechanism, induction angiogenesis. Approach and Results—Four to 6 weeks after permanent coronary artery occlusion, transgenic rats with cardiomyocyte-specific receptor overexpression had less remodeling than their nontransgenic littermates, fibrosis, hypertrophy lung weight, preserved left ventricular ejection fraction wall stress (all P<0.05). Coronary blood flow, measured microspheres, increased in the infarct zone compared littermates (1.4±0.2 versus 0.5±0.08 mL min−1 g−1; P<0.05), which is consistent angiogenesis, as reflected by 20% increase capillary density adjacent infarct. The question arose, how does gene cardiomyocytes induce angiogenesis? identified paracrine...