Emerging therapeutic potential of anti-psychotic drugs in the management of human glioma: A comprehensive review.
作者： Muhamad NA Kamarudin , Ishwar Parhar , None
DOI: 10.18632/ONCOTARGET.26994
关键词: Cell cycle 、 Cancer 、 Astrocytoma 、 Glioma 、 Autophagy 、 Cancer research 、 In vivo 、 Medicine 、 Epigenetics 、 Histone deacetylase
摘要: Despite numerous advancements in the last decade, human gliomas such as astrocytoma and glioblastoma multiforme have worst prognoses among all cancers. Anti-psychotic drugs are commonly prescribed to treat mental disorders cancer patients, growing empirical evidence has revealed their antitumor, anti-metastatic, anti-angiogenic, anti-proliferative, chemo-preventive, neo-adjuvant efficacies various vitro, vivo, clinical glioma models. drawn attention of physicians researchers owing beneficial effects prevention treatment gliomas. This review highlights data on therapeutic potential anti-psychotic chemopreventive, anti-angiogenic agents models via modulation upstream downstream molecular targets involved apoptosis, autophagy, oxidative stress, inflammation, cell cycle vitro vivo preclinical stages patients. The ability modulate signaling pathways multidrug resistance-conferring proteins that enhance efficacy chemotherapeutic with low side-effects exemplifies great neo-adjuvants chemotherapeutics single or multimodal approach. Moreover, confer induce into oligodendrocyte-like cells neuronal-like phenotype reversal epigenetic alterations through inhibition histone deacetylase further rationalize use treatment. improved understanding will provide better information for globally affordable, well-tolerated, effective anticancer glioma.
sci-hub.se 参考文章(127)
V Lisá, B Rittich, H Kovárů, A Spanová, E Lukásová, Estimation of apoptosis in C6 glioma cells treated with antidepressants. Physiological Research. ,vol. 46, pp. 161- 164 ,(1997)
Philip Seeman, Atypical Antipsychotics: Mechanism of Action: The Canadian Journal of Psychiatry. ,vol. 47, pp. 27- 38 ,(2002) , 10.1177/070674370204700106
H-W Cheng, Y-H Liang, Y-L Kuo, C-P Chuu, C-Y Lin, M-H Lee, A T H Wu, C-T Yeh, E I-T Chen, J Whang-Peng, C-L Su, C-YF Huang, Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data Cell Death and Disease. ,vol. 6, ,(2015) , 10.1038/CDDIS.2015.77
L M E Berghauser Pont, R K Balvers, J J Kloezeman, M O Nowicki, W van den Bossche, A Kremer, H Wakimoto, B G van den Hoogen, S Leenstra, C M F Dirven, E A Chiocca, S E Lawler, M L M Lamfers, In vitro screening of clinical drugs identifies sensitizers of oncolytic viral therapy in glioblastoma stem-like cells Gene Therapy. ,vol. 22, pp. 947- 959 ,(2015) , 10.1038/GT.2015.72
Cui Jie Shao, Yun Fei Xia, Ming Wei Wu, Cong Li, Fu Rong Chen, Zhong Ping Chen, Histone deacetylase inhibitor, 2-propylpentanoic acid, increases the chemosensitivity and radiosensitivity of human glioma cell lines in vitro. Chinese Medical Journal. ,vol. 125, pp. 4338- 4343 ,(2012) , 10.3760/CMA.J.ISSN.0366-6999.2012.24.004
Jacqueline J. L. Jacobs, Karin Kieboom, Silvia Marino, Ronald A DePinho, Maarten van Lohuizen, The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus Nature. ,vol. 397, pp. 164- 168 ,(1999) , 10.1038/16476
Richard Near, Adam Lerner, Richard Lee, Eunyi Moon, Sharon Wolda, Lewis Weintraub, Inhibition of PDE3B Augments PDE4 Inhibitor-induced Apoptosis in a Subset of Patients with Chronic Lymphocytic Leukemia Clinical Cancer Research. ,vol. 8, pp. 589- 595 ,(2002)
Christopher L. Bacon, Helen C. Gallagher, John C. Haughey, Ciaran M. Regan, Antiproliferative action of valproate is associated with aberrant expression and nuclear translocation of cyclin D3 during the C6 glioma G1 phase. Journal of Neurochemistry. ,vol. 83, pp. 12- 19 ,(2002) , 10.1046/J.1471-4159.2002.01081.X
Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray, Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer. ,vol. 136, ,(2015) , 10.1002/IJC.29210
Lucilla Bongiorno-Borbone, Arianna Giacobbe, Mirco Compagnone, Adriana Eramo, Ruggero De Maria, Angelo Peschiaroli, Gerry Melino, Anti-tumoral effect of desmethylclomipramine in lung cancer stem cells Oncotarget. ,vol. 6, pp. 16926- 16938 ,(2015) , 10.18632/ONCOTARGET.4700