Macrophage activation and induction of macrophage cytotoxicity by purified polysaccharide fractions from the plant Echinacea purpurea.

摘要: Purified polysaccharides (EPS) prepared from the plant Echinacea purpurea are shown to strongly activate macrophages. Macrophages activated with these substances develop pronounced extracellular cytotoxicity against tumor targets. The activation is brought about by EPS alone and independent of any cooperative effect lymphocytes. Also production secretion oxygen radicals interleukin 1 macrophages increased after EPS. Cells lineage seem be main target for action polysaccharides. has no on T B lymphocytes show a comparatively modest proliferation incubation E. Thus, compounds, which at least in tissue culture completely nontoxic, may suited vivo cells macrophage system cytotoxicity. They therefore relevance infectious systems.