Airway hyperresponsiveness in guinea pigs exposed to acid-coated ultrafine particles.
作者： Lung Chi Chen , Patricia D. Miller , Mary O. Amdur , Terry Gordon
DOI: 10.1080/15287399209531606
关键词: Surgery 、 Endocrinology 、 Pulmonary resistance 、 Pulmonary function testing 、 Adverse health effect 、 Breathing 、 Chemistry 、 Airway hyperresponsiveness 、 Internal medicine 、 Respiratory system 、 Acetylcholine 、 Ultrafine particle
摘要: Although several epidemiological studies have provided evidence that airborne sulfate particles can produce adverse health effects in susceptible individuals, there is only limited data demonstrating respiratory human volunteers and experimental animals at near ambient concentrations. We demonstrated previously the mixing of metal oxide with SO2 under humid conditions produces acid‐coated are significantly more potent causing pulmonary function changes than pure acid droplets. The present study examined nonspecific airway responsiveness to acetylcholine guinea pigs exposed zinc particles. One a half hours after 1‐h exposure aerosols or control atmosphere, resistance (RL) was measured awake, spontaneously breathing before during challenge increasing doses iv (Ach). provocative infusion rate Ach resulted 100% increase RL (PR100) de...
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