Three-month mortality rate and clinical predictors in patients with venous thromboembolism and cancer. Findings from the RIETE registry

摘要: Patients with venous thromboembolism (VTE), and particularly those cancer, are at increased risk of recurrences, major bleeding, short- / medium-term mortality. Data from 35,539 patients (6,075 these cancer), presenting symptomatic VTE in the previous three months enrolled worldwide RIETE registry, were evaluated to assess overall pulmonary embolism (PE)-related mortality, their potential predictors, particular focus on cancer. Overall 3-month mortality total population was 7.9%, death considered PE-related 1.4%. Significantly more died among cancer (26.4%, vs 4.1% no-cancer group, p<0.001). In 3.0% PE-related, compared 1.0% group (p<0.001). Cancer strongest independent factor for both all-cause subgroup advanced disease, reduced mobility, chronic experiencing PE (vs isolated deep vein thrombosis) death. According findings our very large, real-world following an acute episode remains a substantial cause high VTE-related Clinical factors predicting fatal identified this study (cancer, immobility, comorbidities, increasing age, presentation), could be stratification scheme secondary prophylaxis daily practice.