Woven silk fabric-reinforced silk nanofibrous scaffolds for regenerating load-bearing soft tissues
作者： F. Han , S. Liu , X. Liu , Y. Pei , S. Bai
DOI: 10.1016/J.ACTBIO.2013.09.026
关键词: Load bearing 、 Ultimate tensile strength 、 Biomedical engineering 、 SILK 、 Materials science 、 Biocompatibility 、 Soft tissue 、 Silk fabric 、 Regeneration (biology) 、 In vitro cell culture 、 Composite material 、 Biotechnology 、 Biochemistry 、 Molecular biology 、 Biomaterials 、 General Medicine
摘要: Although three-dimensional (3-D) porous regenerated silk scaffolds with outstanding biocompatibility, biodegradability and low inflammatory reactions have promising application in different tissue regeneration, the mechanical properties of scaffolds, especially suture retention strength, must be further improved to satisfy requirements clinical applications. This study presents woven fabric-reinforced nanofibrous aimed at dermal engineering. To improve properties, prepared by lyophilization were reinforced degummed fabrics. The ultimate tensile elongation break strength significantly improved, providing suitable strong enough for stiffness degradation behaviors then regulated after-treatment processes, making more regeneration. vitro cell culture results indicated that these maintained their excellent biocompatibility after being Without sacrifice structure better could facilitate future applications as matrices skin repair.
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