Placental ESRRG-CYP19A1 Expressions and Circulating 17-Beta Estradiol in IUGR Pregnancies.

摘要: Introduction: Sex steroids are regulating factors for intrauterine growth. 17-β Estradiol (E2) is particularly critical to a physiological pregnancy, as increased maternal E2 was correlated lower fetal weight at delivery. The placenta itself primary source of estrogens, synthetized from cholesterol precursors. Cytochrome P450 aromatase (encoded by CYP19A1 gene) rate-limiting enzyme biosynthesis. transcription supported Estrogen Related-Receptor Gamma (ERRγ- ESRRG gene), which thus has an indirect role in placental steroidogenesis. Here we investigated levels and expressions pregnancies with IntraUterine Growth Restriction (IUGR). Methods: Singleton were studied. measured plasma electrochemiluminescence 16 term controls 11 IUGR (classified umbilical artery doppler pulsatility index) elective cesarean section, also 13 during pregnancy gestational age comparable IUGR. analyzed tissue. Maternal/fetal characteristics, molecular data compared among study groups tested correlations. Results: Maternal concentrations significantly decreased When analyzing normal similar IUGR, not different pathological cases. However, delivery positively efficiency. Placental higher tissue vs. controls, specifically female placentas. expression groups. Discussion: We report positive correlation between efficiency, that might indicate disrupted steroidogenesis pregnancies. Moreover, show alterations placentas, possibly indicating compensatory effect the adverse environment, depending on sex. Further studies needed deeper investigate complex interaction molecules involved