Four 6H‐Dibenzo[b,d]pyran‐6‐one Derivatives Produced by the Endophyte Cephalosporium acremonium IFB‐E007
作者： Hua-Wei Zhang , Wu-Yang Huang , Yong-Chun Song , Jing-Rong Chen , Ren-Xiang Tan
关键词: Ic50 values 、 Alternariol monomethyl ether 、 Endophyte 、 Cephalosporium acremonium 、 Endophytic fungus 、 Chemistry 、 Stereochemistry 、 Pyran 、 Trachelospermum jasminoides
摘要: Two novel 6H-dibenzo[b,d]pyran-6-one derivatives, graphislactone G (1) and H (2), besides A (3) alternariol monomethyl ether (4) were isolated from the CHCl3/MeOH 1 : 1 extract of solid-substrate culture Cephalosporium acremonium IFB-E007, an endophytic fungus in Trachelospermum jasminoides (Lindl.) Lem. The structures compounds 1 2 unambiguously established as 2-chloro-7-hydroxy-3,9-dimethoxy-1-methyl-6H-dibenzo[b,d]pyran-6-one 7-hydroxy-3,4,9-trimethoxy-1-methyl-6H-dibenzo[b,d]pyran-6-one, respectively, by a combination spectroscopic analyses. Compound was unique its bearing Cl-atom. Anticancer tests showed that 1–4 had pronounced activities against SW1116 cell with IC50 values 21, 12, 8.5, 14 μg ml−1, respectively.
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