Chitosan/arginine-chitosan polymer blends for assembly of nanofibrous membranes for wound regeneration.
作者： B.P. Antunes , A.F. Moreira , V.M. Gaspar , I.J. Correia
DOI: 10.1016/J.CARBPOL.2015.04.072
关键词: Wound healing 、 Regeneration (biology) 、 Biocompatibility 、 Composite material 、 Biomaterial 、 Nanofiber 、 Biomedical engineering 、 Membrane 、 Extracellular matrix 、 Chitosan 、 Chemistry
摘要: Frequently, skin is subjected to damaging events, such as deep cuts, burns or ulcers, which may compromise the integrity of this organ. To overcome lesions, different strategies have been employed. Among them, wound dressings aimed re-establish native properties and decreased patient pain pursued for a long time. Herein, an electrospun membrane comprised by deacetylated/arginine modified chitosan (CH-A) was produced be used dressing. The obtained results showed that has highly hydrophilic porous three-dimensional nanofibrous network similar found in human extracellular matrix. In vitro data indicate fibroblasts adhere proliferate contact with membranes, thus corroborating their biocompatibility. This nanofiber-based biomaterial also demonstrated bactericidal activity two bacterial strains. vivo application CH-A nanofibers full thickness wounds resulted improved tissue regeneration faster closure, when compared non-modified membranes. Such findings support suitability using dressing near future.
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