Ventilation and breathing pattern during sleep in Duchenne muscular dystrophy.

作者: P.E.M. Smith , R.H.T. Edwards , Peter M.A. Calverley

DOI: 10.1378/CHEST.96.6.1346

关键词: Duchenne muscular dystrophySleep disorderBreathingAnesthesiaPolysomnographyMedicineEnvironmental air flowSleep and breathingRespiratory minute volumeSurgeryTidal volume

摘要: Ventilatory data, including timing and partitioning of ventilation, were obtained from six subjects with advanced Duchenne muscular dystrophy, aged 16 to 22 years, during polysomnography on two consecutive nights; the randomized breathing air or oxygen. Five patients developed oxygen desaturation exceeding 5 percent rapid eye movement (REM) sleep while air. Minute ventilation (the mean at least minutes) was 6.9±0.7 (SEM) L min−1 but fell, owing decreases in both tidal volume frequency, 4.9±0.3 (p

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