Induction of signal transduction pathways related to the pathogenicity of Cryptococcus neoformans in the host environment
作者： Yasuhiko Matsumoto , Saki Azami , Haruka Shiga , Tae Nagamachi , Hikari Moriyama
关键词: Fungus 、 Pathogenic fungus 、 Cryptococcus neoformans 、 Virulence 、 Melanin 、 Signal transduction 、 Biology 、 Host factor 、 Microbiology 、 Mutant
摘要: Cryptococcus neoformans, a human pathogenic fungus, infects immunocompromised humans and causes serious diseases such as cerebral meningitis. C. neoformans controls the expression of virulence factors in response to host environment via various signal transduction pathways. Understanding molecular mechanisms involved infection will contribute development methods prevent treat neoformans-related diseases. produces factors, polysaccharide capsule melanin, escape immunity. Several proteins are reported regulate production factors. In this review, on basis studies using gene-deficient mutants animal models, we outline pathways regulation
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