Helicobacter Pylori Infection is Associated with Worse Severity of Parkinson’s Disease (P3.018)

摘要: OBJECTIVE: To study the impact of Helicobacter pylori (HP) infection on motor function, gastrointestinal symptoms, and quality life in a large cohort Parkinson Disease (PD) patients. BACKGROUND: Some studies have suggested that chronic can aggravate neurodegenerative process PD, targeted intervention could potentially modify course this disabling disease. DESIGN/METHODS: 102 consecutive PD patients underwent 13C urea breath testing blinded evaluations consisting Unified Parkinson’s Rating Scale (UPDRS) including “On”-medication examination (Part III), objective quantitative measures bradykinesia (Purdue Pegboard timed gait), Leeds Dyspepsia Questionnaire, PDQ-39 (a health-related questionnaire). RESULTS: 32.4[percnt] were HP-positive. HP-positive older (68.4±7.3 vs. 63.8±8.6 years, P=0.009) had significantly worse outcomes; UPDRS Part III (34.0±13.0 27.3±10.0, P=0.006), (6.4±3.3 8.0±2.7 pins; P=0.012) gait (25.1±25.4 15.5±7.6 seconds; P=0.042). In multivariate analysis, HP status demonstrated significant main effects gait. The association between these outcomes varied according to age. Indigestion burping more common among Summary Index scores did not differ two groups. CONCLUSIONS: This is first largest cross-sectional demonstrate an positivity severity relation both symptoms. Properly designed treatment trials are needed investigate causal link underlying mechanisms for this. Study Supported by: Malaysian Ministry Higher Education grants High-Impact Research (HIR), E000033 UM.C/625/1/HIR/MOHE/CHAN/11-H-50001-00-A000025 Disclosure: Dr. Tan has nothing disclose. Mahadeva received personal compensation activities with Janssen Pharmaceuticals, Abbott Laboratories, AstraZeneca as speaker. Thalha Kiew Yeat Ng Ang Chow Loke Vadivelu Ibrahim Yong Fox Astra Zeneca, Merz, UCB Pharma, Novartis, Teva Neuroscience, Ipsen, Zambon. research support from Merck Serono Avanir. Marras EMD Serono. Lang AbbVie, Allon Therapeutics, Avanir Biogen Idec, Boehringer Ingelheim Ceregene, Inc., Eli Lilly & Company, Medtronic, Co., Novart Lim GlaxoSmithKline Novartis.