Heterochromatin islands and their dynamic reorganization: a hypothesis for three distinctive features of cellular aging

摘要: The mechanism of cellular aging has been suggested to play an important role in organismic aging, but the molecular linkage between them is not still understood. recent progress studies telomere and telomerase demonstrates their substantial roles aging. On other hand, these also raise controversial issues about generality hypothesis. heterochronic, polymorphic, probabilistic features should be reconsidered critically. In this review, we attempt develop a general scheme for driving force based on our computational studies. Our analyses suggest that global transcriptional repressive structures are essentially involved aging-associated regulation. From theoretical studies, systematic reorganization fundamental heterochromatin island hypothesis proposed give rational explanation three distinctive importance dynamic equilibrium islands discussed