Abstract MP21: Consumption of Nuts and Beans and Risk of Incident Coronary Heart Disease, Stroke, and Diabetes Mellitus: A Systematic Review and Meta-analysis

摘要: BACKGROUND Higher consumption of nuts is linked to lower risk CHD, but relationships with stroke or diabetes are less established. Further, whether consuming beans (legumes) associated stroke, has not been systematically reviewed. OBJECTIVE To investigate and quantify the nut bean intake incident diabetes. METHODS Using MOOSE PRISMA guidelines, we searched multiple databases identify randomized control trials observational studies examining associations Studies were excluded if reporting only intermediate physiologic measures, soft CVD outcomes (e.g., angina), crude estimates. Data extracted independently in duplicate. Generalized least-squares trend estimation was used assess dose-response relationships. Pooled summary estimates calculated by fixed (I2 RESULTS From 2,737 identified abstracts, 24 0 met inclusion criteria, comprising 813,590 individuals 21,149 8,531 24,044 cases. Nut inversely fatal CHD (n=4 studies, 2,794 cases; RR per 1oz/wk: 0.88; 95% CI 0.83, 0.93; I2 0%), non-fatal (n=3, 4,280 0.94; 0.89, 0.98; 14%), (n=4, 16,371 0.99; 61%); ischemic hemorrhagic (n=2, 4,553 cases). Bean also total (n= 4, 10,164 1oz/day: 6%) (n=2; 5561 cases) 2356 Meta-regression age (p 0.04) study duration 0.01) as sources heterogeneity, benefits older greater length follow-up. Evidence for publication bias seen. CONCLUSIONS Our findings support eating reduce More evidence from long-term prospective needed influences