Defining sepsis on the wards: results of a multi-centre point-prevalence study comparing two sepsis definitions.

摘要: Our aim was to prospectively determine the predictive capabilities of SEPSIS-1 and SEPSIS-3 definitions in emergency departments general wards. Patients with National Early Warning Score (NEWS) 3 or above suspected proven infection were enrolled over a 24-h period 13 Welsh hospitals. The primary outcome measure mortality within 30 days. Out 5422 patients screened, 431 fulfilled inclusion criteria 380 (88%) recruited. Using definition, 212 had sepsis. When using Sequential Organ Failure Assessment (SOFA) score ≥ 2, there 272 septic patients, whereas quickSOFA 50 identified. For prediction outcome, sensitivity (95%CI) 65% (54-75%) specificity 47% (41-53%); 86% (76-92%) 32% (27-38%). associated hazard ratio 2.7 (1.5-5.6) 1.6 (1.3-2.5), respectively. Scoring system discrimination evaluated by receiver operating characteristic curves highest for (0.69 (95%CI 0.63-0.76)), followed NEWS (0.58 (0.51-0.66)) (p < 0.001). Systemic inflammatory response syndrome (0.55 (0.49-0.61)) (0.56 (0.49-0.64)) could not predict outcome. definition identified risk. better predictors poor appeared be best tool identifying high risk death sepsis-induced organ dysfunction.