Pathologically examining a minimum of three lymph nodes could better determine node negativity in patients with non-metastatic chromophobe renal cell carcinoma.

摘要: Objective To evaluate the prognostic value of lymph node (LN) involvement for patients with chromophobe renal cell carcinoma (chRCC) and ascertain minimum number LNs that need to be pathologically examined reliably diagnose a patient negative chRCC. Methods From 2004 2014, non-metastatic chRCC receiving radical nephrectomy together lymphadenectomy were identified from Surveillance, Epidemiology End Results (SEER) database. The primary outcome was overall survival (OS). Two hundred forty-six received dissection during surgery. Of patients, 24 (10%) had confirmed positive LN. Multivariate Cox regression model showed LN an independent unfavorable predictor OS (HR = 2.83, 95%CI 1.14-6.98, P 0.024). More importantly, LN(-) at least three dissected significantly better compared when 1-2 (P 0.048). analysis in examination or more could independently predict only (HR≥3LNs 0.362, 95% CI 0.135-0.972, 0.044). Additionally, likelihood finding one higher on ≥3 (15% vs 5%, 0.018). Decision curve found clinical validity '3 examined'-based classification traditional LN(-)/LN(+) classification. Conclusion proportion far neglectable metastasis OS. We recommended should order determine negative.