Involvement of Brain-Derived Neurotrophic Factor in Spatial Memory Formation and Maintenance in a Radial Arm Maze Test in Rats

摘要: Brain-derived neurotrophic factor (BDNF) regulates both short-term synaptic functions and activity-dependent plasticity such as long-term potentiation. In the present study, we investigated role of BDNF in spatial reference working memory a radial arm maze test. The training resulted significant increase mRNA expression hippocampus, although frontal cortex did not change. When learning was inhibited by treatment with 7-nitroindazole, an inhibitor brain nitric oxide synthase, hippocampal occur. To clarify causal relation between formation, examined effects antisense on memory. A continuous intracerebroventricular infusion oligonucleotide impairment learning, sense had no effect. Treatment antisense, but sense, associated reduction protein levels hippocampus. Furthermore, rats, which previously acquired extensive training, impaired There were differences locomotor activity, food consumption, body weight oligonucleotide-treated rats. These results suggest that plays important only also retention and/or recall,