The reversal of anticholinergic intoxication in man with the cholinesterase inhibitor VX.

摘要: SummaryVX, a potent cholinesterase inhibitor, effectively reversed the central effect (delirium) produced by scopolamine and two synthetic anticholinergic compounds in man when VX was administered iv. The therapeutic effectiveness of not diminished previous, simultaneous, or subsequent administration pralidoxime chloride which restored red blood cell inhibition VX. However, orally dose that equivalent depression ineffective.We wish to thank nurses technicians Clinical Research Branch for ward care subjects. We also J. S. Ketchum helpful suggestions during study, A. Cucinell constructive comments on manuscript, Marion P. Royston editorial assistance.Part this report presented at April 1973 meeting Federation American Societies Experimental Biology, Atlantic City, New Jersey.