Influence of gonadotropin-releasing hormone agonist on the effect of chemotherapy upon ovarian cancer and the prevention of chemotherapy-induced ovarian damage: an experimental study with nu/nu athymic mice
作者： Qiong-yan Lin , Yi-feng Wang , Hui-nan Weng , Xiu-jie Sheng , Qing-ping Jiang
关键词: Agonist 、 Gonadotropin-releasing hormone 、 Ovarian cancer 、 Internal medicine 、 Cisplatin 、 Gonadotropin-releasing hormone agonist 、 Endocrinology 、 Anti-Müllerian hormone 、 Medicine 、 Ovary 、 Chemotherapy
摘要: Background and objective Gonadotropin-releasing hormone (GnRH) plays an important role in the regulation of ovarian function cancer cell growth. In this study, we determined whether administration GnRH agonist (GnRHa), triporelin, prior to cisplatin treatment affects and/or prevents cisplatin-induced damage.
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M. Wu, H. Lee, R. E. Bellas, S. L. Schauer, M. Arsura, D. Katz, M. J. FitzGerald, T. L. Rothstein, D. H. Sherr, G. E. Sonenshein, Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells. The EMBO Journal. ,vol. 15, pp. 4682- 4690 ,(1996) , 10.1002/J.1460-2075.1996.TB00845.X
Masato Enari, Hideki Sakahira, Hideki Yokoyama, Katsuya Okawa, Akihiro Iwamatsu, Shigekazu Nagata, A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD Nature. ,vol. 391, pp. 43- 50 ,(1998) , 10.1038/34112
S Grimm, M K Bauer, P A Baeuerle, K Schulze-Osthoff, Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis. Journal of Cell Biology. ,vol. 134, pp. 13- 23 ,(1996) , 10.1083/JCB.134.1.13
C. Wang, NF-B Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation Science. ,vol. 281, pp. 1680- 1683 ,(1998) , 10.1126/SCIENCE.281.5383.1680
M. Grilli, M. Pizzi, M. Memo, P. Spano, Neuroprotection by Aspirin and Sodium Salicylate Through Blockade of NF-κB Activation Science. ,vol. 274, pp. 1383- 1385 ,(1996) , 10.1126/SCIENCE.274.5291.1383
Archontoula Stoffel, Mira Chaurushiya, Bhuvanesh Singh, Arnold J. Levine, Activation of NF-κB and inhibition of p53-mediated apoptosis by API2/mucosa-associated lymphoid tissue 1 fusions promote oncogenesis Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 9079- 9084 ,(2004) , 10.1073/PNAS.0402415101
Atsushi Imai, Tsukasa Ohno, Koji Iida, Tatsuo Fuseya, Tatsuro Furui, Teruhiko Tamaya, GONADOTROPIN-RELEASING HORMONE RECEPTOR IN GYNECOLOGIC TUMORS : FREQUENT EXPRESSION IN ADENOCARCINOMA HISTOLOGIC TYPES Cancer. ,vol. 74, pp. 2555- 2561 ,(1994) , 10.1002/1097-0142(19941101)74:9<2555::AID-CNCR2820740925>3.0.CO;2-X
J M Arencibia, A V Schally, Luteinizing hormone-releasing hormone as an autocrine growth factor in ES-2 ovarian cancer cell line. International Journal of Oncology. ,vol. 16, pp. 1009- 1013 ,(2000) , 10.3892/IJO.16.5.1009
Sung K. Kang, Kwai W. Cheng, Parimal S. Nathwani, Kyung-Chul Choi, Peter C. K. Leung, Autocrine role of gonadotropin-releasing hormone and its receptor in ovarian cancer cell growth. Endocrine. ,vol. 13, pp. 297- 304 ,(2000) , 10.1385/ENDO:13:3:297
Carsten Gründker, Andreas R. Günthert, Robert P. Millar, Günter Emons, Expression of gonadotropin-releasing hormone II (GnRH-II) receptor in human endometrial and ovarian cancer cells and effects of GnRH-II on tumor cell proliferation. The Journal of Clinical Endocrinology and Metabolism. ,vol. 87, pp. 1427- 1430 ,(2002) , 10.1210/JCEM.87.3.8437