The Protein Folding Problem
作者： Ken A. Dill , S. Banu Ozkan , M. Scott Shell , Thomas R. Weikl
DOI: 10.1146/ANNUREV.BIOPHYS.37.092707.153558
关键词: Chemistry 、 Protein structure 、 Protein design 、 Computational chemistry 、 Peptide sequence 、 Native structure 、 Protein structure prediction 、 Computational biology 、 CASP 、 Protein folding 、 Protein engineering
摘要: The “protein folding problem” consists of three closely related puzzles: (a) What is the code? (b) mechanism? (c) Can we predict native structure a protein from its amino acid sequence? Once regarded as grand challenge, has seen great progress in recent years. Now, foldable proteins and nonbiological polymers are being designed routinely moving toward successful applications. structures small now often well predicted by computer methods. And, there testable explanation for how can fold so quickly: A solves large global optimization problem series smaller local problems, growing assembling peptide fragments, first.
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