Effects of morphine dependency and its abstinence on serum concentrations of sex hormones and reproductive system in male rats
作者： Ali Pourmotabbed , namdar yousofvand , Mahnaz Ghowsi
关键词: Libido 、 Hormone 、 Internal medicine 、 Endocrinology 、 Medicine 、 Saline 、 Morphine 、 Sex hormone-binding globulin 、 Testosterone 、 Reproductive system 、 Luteinizing hormone
摘要: Background: The study was performed to investigate the effects of morphine dependency and withdrawal on reproductive system adult male rat(Wistar). Methods: 32 rat divided into 5 groups. Animals in control group (n=8) received normal saline (1ml/kg) twice daily subcutaneously for 30 consecutive days. dependent (10mg/ml/kg). In 2 other groups (n=4) syndrome signs were evaluated with naloxone injection (4mg/kg). Receiving days, animals didn’t receive any drug 14 days (spontaneous withdrawal). Results: data showed that serum levels luteinizing hormone (LH) testosterone as well partial weights prostates seminal vesicles, vesicles contents reduced compared (p<0.05). lower than Conclusion: Results this indicate influence sex concentrations may cause reduction fertility libido decline men.
kowsarpub.com参考文章(18)
Zhifeng Zhou, Linzhi Zhuang, Gueiyuang Zhang, Bilian Xiao, A study of the effect of B-EP and naloxone on the function of the hypothalamo-pituitary-testicular axis of the rat. Journal of Andrology. ,vol. 11, pp. 233- 239 ,(1990) , 10.1002/J.1939-4640.1990.TB03232.X
Steven M. Gabriel, James W. Simpkins, Satya P. Kalra, Pushpa S. Kalra, Chronic Morphine Treatment Induces Hypersensitivity to Testosterone-Negative Feedback in Castrated Male Rats Neuroendocrinology. ,vol. 40, pp. 39- 44 ,(1985) , 10.1159/000124049
G. Wittert, P. Hope, D. Pyle, Tissue distribution of opioid receptor gene expression in the rat. Biochemical and Biophysical Research Communications. ,vol. 218, pp. 877- 881 ,(1996) , 10.1006/BBRC.1996.0156
Harry W. Daniell, Robin Lentz, Norman A. Mazer, Open-Label Pilot Study of Testosterone Patch Therapy in Men With Opioid-Induced Androgen Deficiency The Journal of Pain. ,vol. 7, pp. 200- 210 ,(2006) , 10.1016/J.JPAIN.2005.10.009
M. Markó, D. Römer, Inhibitory effect of a new opioid agonist on reproductive endocrine activity in rats of both sexes Life Sciences. ,vol. 33, pp. 233- 240 ,(1983) , 10.1016/0024-3205(83)90381-8
ANDREA FABBRI, GAIL KNOX, ELLEN BUCZKO, MARIA L. DUFAU, β-Endorphin Production by the Fetal Leydig Cell: Regulation and Implications for Paracrine Control of Sertoli Cell Function* Endocrinology. ,vol. 122, pp. 749- 755 ,(1988) , 10.1210/ENDO-122-2-749
Marilyn E. Carroll, Justin J. Anker, Sex differences and ovarian hormones in animal models of drug dependence. Hormones and Behavior. ,vol. 58, pp. 44- 56 ,(2010) , 10.1016/J.YHBEH.2009.10.001
Theodore J Cicero, LA Davis, MC LaRegina, ER Meyer, MS Schlegel, None, Chronic opiate exposure in the male rat adversely affects fertility. Pharmacology, Biochemistry and Behavior. ,vol. 72, pp. 157- 163 ,(2002) , 10.1016/S0091-3057(01)00751-1
Harry W. Daniell, Hypogonadism in men consuming sustained-action oral opioids. The Journal of Pain. ,vol. 3, pp. 377- 384 ,(2002) , 10.1054/JPAI.2002.126790
Simin Fazelipour, Seyed Babak Kiaei, Zahra Tootian, Adverse effect of heroin hydrochloride on selected male reproductive parameters in mice Comparative Clinical Pathology. ,vol. 19, pp. 565- 569 ,(2010) , 10.1007/S00580-009-0925-5