Neuronal excitation/inhibition balance is set by the need for sleep and the biological clock

摘要: Animal [Vyazovskiy et al., 2011] and human [Huber 2012] data indicate that neuronal excitability linearly increases with time awake. However, recent animal posit synaptic efficacy morphology depend on of day the biological clock [Liston 2013]. Collectively, these point to uncertainties about how brain dynamics are orchestrated by sleepand clock-dependent processes. Dynamic Causal Modelling for electroencephalography (DCM-EEG) provides a validated non-invasive framework inferences in vivo architectures generate electrophysiological measures, based physiologically plausible priors [Friston 2003; Moran 2015]. Here, our aim was apply DCM-EEG EEG evoked responses Transcranial Magnetic Stimulation (EEG-TMS) over prefrontal cortex (PFC, highly sensitive sleep pressure [Finelli 2000]), investigate excitation/inhibition as function need clock.