EGFR (HER) family protein expression and cytogenetics in 219 squamous cell carcinomas of the upper respiratory tract: ERBB2 overexpression independent prediction of poor prognosis.

摘要: OBJECTIVE To retrospectively evaluate the prognostic impact of gene status and protein expression receptor tyrosine kinases HER (human epidermal growth factor related) family in relation to established clinicopathologic parameters squamous cell carcinomas upper respiratory tract. STUDY DESIGN Immunohistochemistry fluorescence situ hybridization for HER1-4 proliferation marker Ki-67 was performed 219 cases head neck related long-term clinical follow-up. Additionally, chromosomal instability analyzed. RESULTS High HER1 HER2 present 49.4% 6.6% tumors, respectively. Expression HER3 HER4 appeared negative or inconspicuous. A amplification occurred 5.2% whereas none tumors showed an HER2-4 loci. In univariate overall survival analysis a could be demonstrated high (p < 0.01), advanced local tumor lymph node metastasis presence residual after surgical therapy proliferative activity (Ki-67; p = 0.02) 0.01). According multivariate analysis, strongest predictors were 0.01) 0.03). CONCLUSION Overexpression harbor additional on disease-specific prove independent factors carcinomas.