Prognostic value of changes in lean and fat mass in alcoholics.

摘要: Summary Background & aims The prognostic value of nutritional status and/or lean and fat mass assessed by dual-energy X-ray absorptiometry (DEXA) has been widely analyzed, in both alcoholics non-alcoholics. However, the changes over time scarcely studied, nor effect alcohol abstinence on these changes. Methods From an initial cohort 113 alcoholic patients, 70 prospectively underwent two DEXA assessments six months apart. One hundred five patients (including 66 those who assessments) were followed up for 34.9 ± 36.4 (median = 18 months, interquartile range = 7.25–53.75 months). During this follow-up period, 33 died 20 had undergone a second assessment). Results Forty-two undergoing assessment abstained from alcohol. Of these, 69.04% (29) gained left arm mass, compared with only 35.71% (10 28) continued drinking ( χ 2  = 7.46; p  = 0.006). Similar results observed regarding right  = 4.68;  = 0.03) leg  = 7.88;  = 0.005). no associations found between parameters. Analysis means Kaplan–Meier curves showed that loss total all significantly associated reduced survival. within 30 evaluation, significant parameters related to mortality, but association mortality. Conclusions Loss period after first is worse prognosis alcoholics, irrespective whether they stop during or not. Continued greater not mass.