Reduction of stress-induced analgesia but not of exogenous opioid effects in mice lacking CB1 receptors

作者: Olga Valverde , Catherine Ledent , Francoise Beslot , Marc Parmentier , Bernard P. Roques

DOI: 10.1046/J.1460-9568.2000.00929.X

关键词: CannabinoidCannabinoid receptorAgonistInternal medicineμ-opioid receptorPharmacologyMorphineChemistryOpioidEndogenous opioidEndocrinologyReceptor

摘要: CB1 cannabinoid receptors are widely distributed in the central nervous system where they mediate most of cannabinoid-induced responses. Here we have evaluated interactions between and endogenous opioid by assaying a number well-characterized responses, e.g. antinociception stress-mediated effects, on mutant mice which receptor gene was invalidated. The spontaneous responses to various nociceptive stimuli (thermal, mechanical visceral pain) were not changed mice. Furthermore, absence did modify antinociceptive effects induced different agonists: morphine (preferential mu agonist), D-Pen2-D-Pen5-enkephalin (DPDPE) deltorphin II (selective delta agonists), U-50,488H kappa agonist) hot-plate tail-immersion tests. In contrast, stress-induced mediated modified mutants. Indeed, these mutants exhibit following forced swim water at 34 degrees C presented decrease immobility previous exposure electric footshock. However, 10 preserved These results indicate that involved exogenous opioids, but physiological interaction systems is necessary allow development opioid-mediated stress.

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