A new member of the ETS family fused to EWS in Ewing tumors

摘要: As a result of chromosome translocations, the EWS gene is fused to variety transcription factors in human solid neoplasia. In Ewing tumors can be four different members ETS family, namely FLI-1, ERG, ETV1 and E1AF. We have identified new member called FEV, which subset tumors. FEV encodes 238 amino acid protein contains an DNA binding domain closely related that FLI-1 ERG. However, N-terminal portion only 42 acids long suggests lacking important regulatory domains contained ERG parts. The C-terminal end rich alanine residues may indicate repressor. encoded by three exons located on 2. expression was detected adult prostate small intestine but not other nor fetal tissues, thus indicating has restricted pattern. Following scheme similar previously described translocations tumors, t(2;22) translocation fuses FEV.