Optimized inhalation aerosols. I. The effects of spherical baffle size and position upon the output of several pressurized nonaqueous suspension formulations.

摘要: Baffles contained in conventional actuators may be a convenient alternative to some of the extension devices used presently with metered-dose inhalers (MDIs). Actuators were modified determine whether baffles could decrease output large “nonrespirable” droplets. These tested using series nonaqueous suspension aerosols containing 0.1 2.0% micronized disodium fluorescein (DF) as model drug, stabilized by sorbitan trioleate constant blend fluorocarbons 11, 12, and 114. A 25-µl metering volume was throughout. Aerosol characterized cascade impaction. Baffle size position had pronounced effects on actuator retention aerosol output. Increasing baffle resulted increased actuator. The total MDI “respirable” range (aerodynamic diameter, Dae, <5.5 µm) greater unbaffled than all baffled actuators. However, respirable fraction (DF Dae µm: DF leaving actuator), R, when compared their controls. For example, for 0.1% DF, 0.14% surfactant formulation, R from 0.40 (unbaffled) 0.71 incorporation 0.6-cm-diameter sphere 1.3 cm jet In these cases, segregation occurred due droplet inertia high velocity gas flows. at expense obviate undesirable clinical effects.