Ferritins, iron uptake and storage from the bacterioferritin viewpoint.

摘要: Ferritins constitute a broad superfamily of iron storage proteins, widespread in all domains life, aerobic or anaerobic organisms. isolated from bacteria may be haem-free contain haem. In the latter case they are called bacterioferritins. The primary function ferritins inside cells is to store ferric form. A secondary detoxification protection against O2 and its radical products. Indeed, for bacterioferritins this likely their function. bacteroferritins have essentially same architecture, assembling 24mer cluster form hollow, roughly spherical construction. review, special emphasis given structure ferroxidase centres with native iron-containing sites, since oxidation ferrous by molecular oxygen takes place these sites. Although present other ferritins, specific entry route iron, coupled reaction, has been proposed described some structural studies. Electrostatic calculations on few selected proteins indicate further ion channels assumed an later mineralization processes core formation.